4 edition of Potassium Channels in Cardiovascular Biology found in the catalog.
Written in English
|Contributions||Stephen L. Archer (Editor), Nancy J. Rusch (Editor)|
|The Physical Object|
|Number of Pages||932|
1. Pharmacol Ther. Apr;90(1) KCNQ potassium channels: physiology, pathophysiology, and pharmacology. Robbins J(1). Author information: (1)Sensory Function Group, Centre for Neuroscience Research, King's College, Guy's Campus, London SE1 1UL, UK. [email protected] KCNQ genes encode a growing family of six transmembrane Cited by: Cardiac potassium channels maintain the rhythmicity of the heartbeat by repolarizing cardiomyocytes such that the electrical and contractile machineries stay in sync. The two major voltage-gated potassium currents responsible for repolarization phase in human cardiomyocytes are cardiac I Ks and I Kr.
Summary Potassium ions K+ ions are vital in physiological processes, particularly with regard to the cardiovascular system. Modulators influence the channels through which these ions flow and the research into modulator drugs of these channels is the subject of rapidly-advancing research. The vessel wall is an intricate structure composed of three layers: the intima (consisting of endothelial cells), media (consisting of smooth muscle cells and elastic fibers), and externa (consisting of the extracellular matrix scaffold). The homeostasis of the vasculature depends on the consistent function of each layer. In the vascular system, potassium channels are well Author: Yan-Rong Zhu, Xiao-Xin Jiang, Peng Ye, Shao-liang Chen, Dai-Min Zhang.
Ion channels are essential for basic cellular function and for processes including sensory perception and intercellular communication in multicellular organisms. Voltage-gated potassium (Kv) channels facilitate dynamic cellular repolarization during an action potential, opening in response to membrane depolarization to facilitate K+ efflux. In both excitable and Cited by: The amino acid sequences of many different ion channel proteins have been determined, and in a few cases the X-ray crystal structure of the channel is known as well. Based on their structure, the majority of ion channels can be classified into six or seven superfamilies. For potassium-selective channels, which are among the best-characterized ion channels, four homologous .
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Potassium Channels in Cardiovascular Biology. Editors: Archer, Stephen L., Rusch, Nancy (Eds.) Free Preview. Buy this book eBook ,39 € price for Spain (gross) Buy eBook ISBN ; Digitally watermarked, DRM-free; Included format: EPUB, PDF; ebooks can be used on all reading devices.
Potassium channels (K +) are membrane-spanning proteins which serve many important functions and are becoming a hot topic in physiology.K + channels determine or modulate many functions of vascular smooth muscle, endothelial and inflammatory cells, and thus are central to regulation of arterial tone and control of cell proliferation.
They are also promising targets for. Get this from a library. Potassium channels in cardiovascular biology. [Stephen L Archer; Nancy Jean Rusch;] -- Potassium channels (K+) are membrane-spanning proteins which serve many important functions and are a hotly debated topic in physiology.
This book highlights the latest discoveries on the role of K+. Get this from a library. Potassium Channels in Cardiovascular Biology. [Stephen L Archer; Nancy J Rusch] -- Potassium channels (K+) are membrane-spanning proteins which serve many important functions and are becoming a hot topic in physiology.
K+ channels determine or modulate many functions of vascular. Potassium channels (K+) are membrane-spanning proteins which serve many important functions and are a hotly debated topic in physiology. This book highlights the latest discoveries on the role of K+ channels in the heart and blood vessels in normal physiology and a.
Potassium channels (K+) are membrane-spanning proteins which serve many important functions and are becoming a hot topic in physiology. K+ channels determine or modulate many functions of vascular smooth muscle, endothelial and inflammatory cells, and thus are central to regulation of arterial tone and control of cell : Springer US.
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Daniel L. Menkes MD, in Neuromuscular Disorders: Treatment and Management, Potassium Channels. Voltage-gated potassium channels may be viewed as the “brakes” on the sensory system in that they repolarize active neurons to the resting state.
19 Potassium channel, voltage-gated KQT-like subfamily (KCNQ) (K v 7) channels are responsible for the inhibitory M. Potassium is the main intracellular ion for all types of cells, while having a major role in maintenance of fluid and electrolyte balance. Potassium is necessary for the function of all living cells, and is thus present in all plant and animal tissues.
It is found in especially high concentrations within plant cells, and in a mixed diet, it is most highly concentrated in fruits. Potassium Channels in Cardiovascular Biology.
Potassium Channels in Cardiovascular Biology. Nattfi., Stanley This is an encyclopedic compendium dealing with a vast subject. Anyone doubting the vastness of the subject need only look through this volume's pages of text, dealing with the molecular biology, physiology.
Potassium channels have a tetrameric structure in which four identical protein subunits associate to form a fourfold symmetric (C 4) complex arranged around a central ion conducting pore (i.e., a homotetramer).Alternatively four related but not identical protein subunits may associate to form heterotetrameric complexes with pseudo C 4 symmetry.
All potassium channel subunits have. Potassium channels form a huge superfamily of ion channels with diverse properties. Among them, Ca 2+-activated potassium channels (K + Ca 2+) are very interesting due to their dual characteristic of being activated by cytosolic increases of Ca 2+ and by alterations in the membrane electric potential (Guéguinou et al., ).
Potassium channels are largely down-regulated in cardiac disease: electrical remodelling. The HERG and KvLQT1 subunits were identified based on the genetic study of patients with the congenital long QT syndrome and numerous mutations have been identified.
Incorporation of the abnormal subunits in the channel tetramer causes mostly a Cited by: Potassium in biology explained. Potassium is the main intracellular ion for all types of cells, while having a major role in maintenance of fluid and electrolyte balance.
Potassium is necessary for the function of all living cells, and is thus present in all plant and animal tissues. K + channels play a critical role in cardiac electrophysiology, and their dysfunction links intracellular signalling, metabolism, remodelling and arrhythmogenesis in many cardiovascular diseases.
Below, we discuss our current understanding of cardiac K + channel types and mechanisms for their (dys) by: from book Potassium Channels in Cardiovascular Biology (pp) Voltage-Gated Potassium Channels in the Myocardium Chapter January with 13 Reads.
In Potassium Channels: Methods and Protocols, experts in the field present a range of experimental approaches that have been developed to investigate potassium channel structure, function, pharmacology, cell biology, gene expression, and their role in disease.
Many of these techniques study potassium channels as cellular proteins as well as the Format: Hardcover. Request PDF | Potassium Channels in the Circulation of Skeletal Muscle | Skeletal muscle represents 40% of body mass and contributes substantially in.
Potassium channels are subdivided into families, based on their structural and functional properties. The largest family consists of potassium channels that activated by membrane depolarization, with other families consisting of channels that are either activated by a rise of intracellular calcium ions or are constitutively active.
This issue of Cardiac Electrophysiology Clinics, edited by Drs. Mohammad Shenasa and Stanley Nattel, will review Cardiac Potassium Channel Disorders in depth.
Topics covered include but are not limited to: Molecular Biology of Cardiac Potassium Channels. Abstract. Vascular endothelium appears to be a unique organ that not only responds to numerous hormonal and chemical signals but also senses changes in physical parameters, such as changes in blood flow through shear stress and changes in blood pressure through by: 4.
Potassium channels play important roles in vital cellular signaling processes in both excitable and nonexcitable cells. Over 50 human genes encoding various K+ channels have been cloned during the past decade, and precise biophysical properties, subunit stoichiometry, channel assembly, and modulation by second messenger and ligands have been elucidated to Cited by: 1.
Physiol Rev. Jan;76(1) Molecular physiology of cardiac potassium channels. Deal KK(1), England SK, Tamkun MM. Author information: (1)Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
The cardiac action potential results from the complex, but precisely regulated, movement of ions across the Cited by: